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Nov.14: Frederick Banting（世界糖尿病日（World Diabetes Day）/ hole punch


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The origins of the hole punch date back to Germany via Matthias Theel, where two early patents for a device designed to "punch holes in paper" have since been discovered. Friedrich Soennecken filed his patent on 14 November, 1886, for his Papierlocher für Sammelmappen.

Hole punch - Wikipedia

https://en.wikipedia.org/wiki/Hole_punch



羅益華
2016年11月14日 9:09
今天（2016/11/14）週一是世界糖尿病日（World Diabetes Day）。
1992年世界糖尿病聯盟（International Diabetes Federation, IDF）為了感謝醫治糖尿病病患的加拿大生理學家 Frederick Banting（11/14/1891 ~ 2/21/1941），決定於每年 Sir Frederick Grant Banting 醫師的生日（11/14）訂為世界糖尿病日。中華民國糖尿病學會的網頁有更為詳盡的來由說明。（http://www.endo-dm.org.tw/dia/exchange/world.asp）
谷歌於今天以 Google Doole 紀念 Banting 醫師的125歲誕辰日。（https://goo.gl/8L7ghU）（On November 14, 2016. Google showed doodle for the 125th birthday of Frederick Banting.）
Frederick Banting 在醫學院碩班學生 Charles Best 協助下，從動物胰腺萃取胰島素，發現胰臟的萃取液可降低糖尿病狗的高血糖，以及改善其他的糖尿病症狀。由於胰島素的發現，以及臨床治療糖尿病的傑出貢獻，Frederick Banting 在1923年與 John James Rickard Macleod 分享諾貝爾生理學醫學獎的桂冠榮銜。
胰島素作用多樣且機制複雜，當年的發現未必盡窺全貌。直到1955年英國的 Frederick Sanger 方才完成純化及結構決定， Sanger 也因此成就獲頒1958年的諾貝爾化學獎。
以胰島素研究而榮獲諾貝爾獎桂冠的學者尚有1977年的生理醫學獎得主 Rosalyn Yalow。Yalow 女士與同僚 Solomon Berson 發現長期注射胰島素的糖尿病病患的血中含有某種球蛋白，能與胰島素產生結合。經分析後發現該球蛋白是針對胰島素的抗體。因人體本身自有胰島素產生，因此對胰島素產生抗體相當不可思議。兩位科學研究者將發現以論文投遞期刊《臨床研究期刊》，不過卻遭到退稿。20年後獲頒諾貝爾獎榮銜，Yalow 女士特將當年的退稿信函改在《科學》期刊上發表，自我陶侃。

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